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Pseudouridine modifications influence binding of aminoglycosides to helix 69 of bacterial ribosomes

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB02147J, PaperYogo Sakakibara, Christine S ChowDevelopment of antibiotics that target new regions of functionality is a possible way to overcome antibiotic resistance. In this study, the interactions of aminoglycoside antibiotics with helix 69 of the...The content of this RSS Feed (c) The Royal Society of Chemistry

Computational Characterization of the Mechanism for the Light-Driven Catalytic Trichloromethylation Of Acylpyridines

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB01826F, PaperVictor M Fernandez-Alvarez, Feliu MaserasThe computational characterization of the mechanism for complex reactions involving the photoactivation of transition metal compounds remains a challenge for theoretical chemistry. In this work we show how the application...The content of this RSS Feed (c) The Royal Society of Chemistry

On the Regiochemical Differences between Pd-Catalyzed Heterocyclization-Allylation and -Arylation Reactions of Alkynylbenzamides: Preparation of 4-Allyl-isochromen-1-imines and Computational Study

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB02117H, PaperRosana Alvarez, Unai Vilar, Youssef Madich, Jose M. AurrecoecheaThe Pd(0)-catalyzed cyclization-allylation reactions of 2-alkynylbenzamides proceed with high regioselectivity to afford the 6-endo-cyclization-derived products 4-allyl-isochromen-1-imines.

A Convenient Synthesis of 1-Aryl-1H-1,2,3-triazoles from Aliphatic Substrates

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB02035J, PaperQiang Wang, Xiaonan Shi, Xinying Zhang, Xuesen FanA convenient synthesis of 1-aryl-1H-1,2,3-triazoles through the one pot cascade reactions of alkynes with aliphatic azides and allenic ketones is presented. Mechanically, the formation of the title compounds involves a...The content of this RSS Feed (c) The Royal Society of Chemistry

ESIPT-Induced Fluorescent o-Hydroxycinnamate: Self-Monitoring Phototrigger for Prompt Image-Guided Uncaging of Alcohols

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB02280H, PaperAmrita Paul, Rakesh Mengji, Olive Abraham Chandy, Surajit Nandi, Manoranjan Bera, Avijit Jana, Anakuthil Anoop, Pradeep N.D. SinghThe o-hydroxycinnamate derivatives are well known phototriggers for fast and direct release of alcohols and amines without proceeding through the cleavage of carbonate or carbamate linkages.

Enantioselective Synthesis of Spiro-oxindole-based 3,4-Dihydropyrroles via a Michael/Cyclization Cascade of 3-Aminooxindoles with 2-Enoylpyridines

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB02138K, PaperBaodong Cui, Yu Chen, Jing Shan, Lei Qin, Changlun Yuan, Yi Wang, Wen-Yong Han, Nanwei Wan, Yong-Zheng ChenAn organocatalytic and highly diastereo- and enantioselective reaction of 3-aminooxindoles with 2-enoylpyridines for the synthesis of chiral spiro[pyrrolidin-3,2'-oxindole] derivatives has been achieved.

A Reevaluation of the Origin of the Rate Acceleration for Enzyme-Catalyzed Hydride Transfer.

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB01652B, Review ArticleJohn P. Richard, Tina Amyes, Archie ReyesThere is no consensus of opinion on the origin of the large rate accelerations observed for enzyme-catalyzed hydride transfer. The interpretation of recent results from studies on hydride transfer reactions...The content of this RSS Feed (c) The Royal Society of Chemistry

In silico analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB02281F, PaperAtsushi Kato, Izumi Nakagome, Shinpei Nakagawa, Kyoko Kinami, Isao Adachi, Sarah F. Jenkinson, Jerome Desire, Yves Bleriot, Robert J. Nash, George W J Fleet, Shuichi HironoThe affinity of a series of iminosugar-based inhibitors exhibiting various ring sizes toward Hex A and their essential interactions with the enzyme active site were investigated.

Synthetically useful variants of industrial lipases from Burkholderia cepacia and Pseudomonas fluorescens

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB01823A, PaperKazunori Yoshida, Masakazu Ono, Takahiro Yamamoto, Takashi Utsumi, Satoshi Koikeda, Tadashi EmaIndustrial enzymes called lipase PS (LPS) and lipase AK (LAK), which originate from Burkholderia cepacia and Pseudomonas fluorescens, respectively, are synthetically useful biocatalysts.

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