Ubiquitin binds the Amyloid ? peptide and interferes with its clearance pathways

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Chem. Sci., 2019, Accepted ManuscriptDOI: 10.1039/C8SC03394C, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Bellia, Valeria Lanza, Sara García-Viñuales, Ikhlas Mohamed Mohamud Ahmed, Adriana Pietropaolo, Claudio Iacobucci, Gaetano Malgieri, Gianluca D'Abrosca, Roberto Fattorusso, Vincenzo Giuseppe Nicoletti, Diego Sbardella, Grazia Raffaella Tundo, Massimo Coletta, Luciano Pirone, Emilia Pedone, Damiano Calcagno, Giuseppe Grasso, Danilo MilardiSeveral lines of evidence point to a compromised proteostasis associated to a reduction of the Ubiquitin Proteasome System (UPS) activity in patients affected by Alzheimer’s Disease (AD) and suggest that...The content of this RSS Feed (c) The Royal Society of Chemistry

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