Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt

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Chem. Sci., 2019, Advance ArticleDOI: 10.1039/C8SC05212C, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Niklas Uhlenbrock, Steven Smith, Jörn Weisner, Ina Landel, Marius Lindemann, Thien Anh Le, Julia Hardick, Rajesh Gontla, Rebekka Scheinpflug, Paul Czodrowski, Petra Janning, Laura Depta, Lena Quambusch, Matthias P. Müller, Bernd Engels, Daniel RauhStructure-based driven synthesis and biological evaluation provide innovative novel covalent-allosteric Akt inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

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