Origin of metastable oligomers and their effects on amyloid fibril self-assembly

Chem. Sci., 2018, Accepted ManuscriptDOI: 10.1039/C8SC01479E, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Filip Hasecke, Tatiana Miti, Carlos Perez, Jeremy Barton, Daniel Scholzel, Lothar Gremer, Clara S. R. Gruning, Garrett Matthews, Georg Meisl, Tuomas Knowles, Dieter Willbold, Philipp Neudecker, Henrike Heise, Ghanim Ullah, Wolfgang Hoyer, Martin MuscholAssembly of rigid amyloid fibrils with their characteristic cross-[small beta] sheet structure is a molecular signature of numerous neurodegenerative and non-neuropathic disorders. Frequently large populations of small globular amyloid oligomers (gOs)...The content of this RSS Feed (c) The Royal Society of Chemistry

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