Organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons

Org. Biomol. Chem., 2018, Accepted ManuscriptDOI: 10.1039/C8OB00707A, CommunicationYuan Luo, Ke-Xin Xie, Deng-Feng Yue, Xiao-Mei Zhang, Xiao-Ying Xu, Weicheng YuanAn organocatalyzed asymmetric Mannich reaction of pyrazoleamides and cyclic trifluoromethyl ketimines with a chiral bifunctional amine-squaramide as the catalyst was developed. A wide range of trifluoromethyl dihydroquinazolinone derivatives bearing adjacent...The content of this RSS Feed (c) The Royal Society of Chemistry

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