Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation

Chem. Sci., 2020, 11,2155-2160DOI: 10.1039/C9SC05036A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liping Zuo, Jingjing Ding, Changkun Li, Feng Lin, Peng R. Chen, Peilin Wang, Guihong Lu, Jinfeng Zhang, Li-Li Huang, Hai-Yan XieSpatiotemporally controlled activation: Dox-TCO loaded low pH-sensitive nanovehicles and Tz-containing MMP-2-sensitive nanocarriers simultaneously dissociated in tumor microenvironment, with Dox locally liberated through IEDDA biorthogonal reaction.The content of this RSS Feed (c) The Royal Society of Chemistry

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