Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation

Chem. Sci., 2020, Advance ArticleDOI: 10.1039/C9SC05036A, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Liping Zuo, Jingjing Ding, Changkun Li, Feng Lin, Peng R. Chen, Peilin Wang, Guihong Lu, Jinfeng Zhang, Li-Li Huang, Hai-Yan XieSpatiotemporally controlled activation: Dox-TCO loaded low pH-sensitive nanovehicles and Tz-containing MMP-2-sensitive nanocarriers simultaneously dissociated in tumor microenvironment, with Dox locally liberated through IEDDA biorthogonal reaction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry

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