Construction of bridged cyclic N,O-ketal spirooxindoles through a Michael addition/N,O-ketalization sequence

Org. Biomol. Chem., 2018, 16,1751-1759DOI: 10.1039/C8OB00306H, PaperYanshuo Zhu, Jia Guo, Shaojing Jin, Jiaomei Guo, Xuguan Bai, Qilin Wang, Zhanwei BuThe first highly diastereoselective TfOH-catalyzed Michael addition/N,O-ketalization sequence of 3-aminooxindoles and ortho-hydroxychalcones was achieved to afford a wide range of bridged cyclic N,O-ketal spirooxindoles in 41-97% yields.The content of this RSS Feed (c) The Royal Society of Chemistry

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