Construction of Bridged Cyclic N,O-Ketal Spirooxindoles through a Michael Addition/N,O-Ketalization Sequence

Org. Biomol. Chem., 2018, Accepted ManuscriptDOI: 10.1039/C8OB00306H, PaperYan-Shuo Zhu, Jia Guo, Shao-Jing Jin, Jiao-Mei Guo, Xu-Guan Bai, Qi-Lin Wang, Zhanwei BuThe first highly diastereoselective TfOH-catalyzed Michael addition/N,O-ketalization sequence of 3-aminooxindoles and ortho-hydroxychalcones was achieved, delivering a wide range of bridged cyclic N,O-ketal spirooxindoles with complex and strained structures in 41-97%...The content of this RSS Feed (c) The Royal Society of Chemistry

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