Conformational landscape of Epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket

Chem. Sci., 2018, Accepted ManuscriptDOI: 10.1039/C8SC01262H, Edge Article Open Access &nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Srinivasaraghavan Kannan, Gireedhar Venkatachalam, Hong Hwa Lim, Uttam Surana, Chandra VermaActivating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancers (NSCLC). Small molecule inhibitors targeted at these mutants have...The content of this RSS Feed (c) The Royal Society of Chemistry

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