Conformation-Guided Analogue Design Identifies Potential Antimalarial Compounds through Inhibition of Mitochondrial Respiration

Org. Biomol. Chem., 2018, Accepted ManuscriptDOI: 10.1039/C8OB01257A, CommunicationErik M Larsen, Chia-Fu Chang, Tomoyo Sakata-Kato, Joseph W. Arico, Vince M. Lombardo, Dyann F Wirth, Richard E TaylorThe synthesis of a 2-methyl-substituted analogue of the natural product, neopeltolide, is reported in an effort to analyze the importance of molecular conformation and ligand-target interactions in relation to biological...The content of this RSS Feed (c) The Royal Society of Chemistry

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