Base-mediated intramolecular one-pot double-cyclization of epoxide-tethered 2-fluorobenzenesulfonamides: an avenue to 1,4-benzoxazine-fused benzothiaoxazepine-1,1-dioxides

Org. Biomol. Chem., 2019, Accepted ManuscriptDOI: 10.1039/C9OB02377A, CommunicationJonali Das, Biraj Jyoti Borah, Sajal Kumar DasHerein, we describe the synthesis of hitherto unknown 1,4-benzoxazine-fused benzothiaoxazepine-1,1-dioxides by a NaH-promoted intramolecular one-pot double-cyclization of epoxide-tethered 2-fluorobenzene sulfonamides. Mechanistically, the reactions proceed via an intramolecular epoxide ring-opening followed...The content of this RSS Feed (c) The Royal Society of Chemistry

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