Unprecedented formation of 3-(tetrahydrofuran-2-yl)-4H-chromen-4-one in the reaction between 3,3a-dihydro-9H-furo[3,4-b]chromen-9-one with malononitrile

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB00904F, PaperJie-Jie Liu, Liang Cheng, Hong-Yan Huang, Feng Wei, Dong Wang, Li LiuChromone skeletons are widespread among natural products as well as bioactive molecules. Here, we describe an unprecedented reaction of furo[3,4-b]chromen-9-one with malononitrile to afford 3-(tetrahydrofuran-2-yl)-4H-chromen-4-ones.

Isonucleotide Incorporation into Middle and Terminal siRNA Duplexes Exhibits High Gene Silencing Efficacy and Nuclease Resistance

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB01065F, PaperYuan Ma, Shuang Liu, Yusi Wang, Yuanhe Zhao, Ye Huang, Lijun Zhong, Zhu Guan, Li-He Zhang, Zhenjun YangIn this study, we introduced a pair of nucleotide enantiomers, D-/L-isonucleotides (D-/L-isoNA), to examine the interactions between siRNAs and their relative proteins.

Self-assembled artificial viral capsid bearing coiled-coils at the surface

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB00998D, PaperKazunori Matsuura, Seiya FujitaIn order to construct artificial viral capsids bearing complementary dimeric coiled-coils on the surface, [small beta]-annulus peptide bearing a coiled-coil forming sequence at the C-terminal ([small beta]-annulus-coiled-coil-B) was synthesized by a native...The content of this RSS Feed (c) The Royal Society of Chemistry

Sulfinyl Isobutyramide as an Auxiliary for Palladium(II)-Catalyzed C-H Arylation and Iodination of Benzylamine Derivatives

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB01163F, CommunicationRui Wang, Yongzheng Ding, Gang LiA novel readily available bidentate 2-methylsulfinyl isobutyramide directing group has been developed for benzylamine derivatives. It promoted ortho-C-H arylation and iodination of various substrates in good to excellent yields. The...The content of this RSS Feed (c) The Royal Society of Chemistry

Stereoselective Synthesis of Enamino Ketones Through Aza-Michael/Hydrolysis Cascade

Org. Biomol. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7OB01032J, CommunicationHai-Lei Cui, Li-Jie Peng, Hai-Lin Zhou, Xiao-Lin You, Xiao-Jie JiangWe have developed a mild, convenient and efficient synthesis of highly functionalized (Z)-[small beta]-enamino ketones from readily available 3,4-dihydroisoquinoline imines and ynones through aza-Michael/hydrolysis cascade.

Compartmentalization of ABC triblock copolymer single-chain nanoparticle via coordination driven orthogonal self-assembly

Polym. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7PY00582B, PaperZhigang Cui, Hui Cao, Yi Ding, Pan Gao, Xinhua Lu, Yuanli CaiWe herein present supramolecular compartmentalization of ABC triblock copolymer single-chain nanoparticle (SCNP) using coordination-driven orthogonal intramolecular self-assembly.

Advantages and Limitations of Diisocyanates in Intramolecular Collapse

Polym. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7PY00712D, PaperFeng Wang, Charles E. DiesendruckA comprehensive examination of the synthesis of single chain polymer nanoparticles (SCPNs) from a copolymer of methyl acrylate (MA) and 2-hydroxyethyl acrylate (HEA) via the intra-chain urethane formation by using...The content of this RSS Feed (c) The Royal Society of Chemistry

Mussel-inspired thermoresponsive polymers with tunable LCST by Cu(0)-LRP for the construction of smart TiO2 nanocomposites

Polym. Chem., 2017, Accepted ManuscriptDOI: 10.1039/C7PY00736A, PaperDonghao Wang, Shutong Guo, Qiang Zhang, Paul Wilson, David HaddletonIn this study, we report on the synthesis of thermoresponsive polymers with different microstructures, precisely tunable lower critical solution temperature (LCST) and terminal catechol anchors by copper (0) mediated living...The content of this RSS Feed (c) The Royal Society of Chemistry

UK terror threat 'linked to wars abroad'

The Labour leader will say UK foreign policy must change, as campaigning resumes after the Manchester attack.

Marawi fighting: Foreign fighters 'among militants' in Philippine city

It is a rare admission by authorities that local jihadists are working with international groups.

Sarah Taylor: England's wicketkeeper-batter explains her recovery from 'mental injury'

Sarah Taylor is "still not the finished article" after a break to deal with anxiety problems, but is "ready" for this summer's World Cup.

Africa's week in pictures: High fives, robot wars and lanterns

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Manchester attack: Police make tenth arrest

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Alex Oxlade-Chamberlain: Arsenal FA Cup win would make it a 'better season'

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Trump readies for 'robust' G7 summit in Sicily

Leaders of the world's major economies will discuss trade, security and climate change.

Mario Testino to display his 'precious' art pieces

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India opens longest bridge on China border

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Gianforte wins Montana vote despite 'body slam' charge

US Republican Greg Gianforte, charged with assaulting the Guardian's Ben Jacobs, is elected to Congress.

Indian acid-attack bride finds love from a wrong number

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Did French president snub Donald Trump at Nato summit?

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Trump Russia inquiry: Kushner under FBI scrutiny - US media

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FA Cup final: The funniest moments from this season's tournament

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Greek goddess statue removed in Bangladesh after Islamist outcry

Bangladeshi Islamist groups said the statue of Themis - the goddess of justice - hurt religious sentiment.

Can fish skin help treat burns?

Doctors in Brazil are experimenting with a new treatment for burns by using fish skin.

SOS mystery in remote Western Australia stumps police

A distress signal spotted in a remote region prompts fears that someone could be missing.

Learn Russian? Which languages Americans study and why

John Kerry joked about Americans learning Russian, but global politics do influence languages studied.

It's not just Windows anymore: Samba has a major SMB bug

First, it was Microsoft's turn to deal with a terrible SMB security hole, WannaCry. Now, it's the open-source SMB server Samba's turn.

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